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Fujian / Qinghai H5N1 Recombinant At Qinghai Lake
The 08 May. 2010 at 23:20Last newsComments (0)Add a comment
Recombinomics Commentary 21:50
May 8, 2010
Sequences from a great crested grebe were released by Harbin Veterinary Research Institute in China. Like the recently released 10 Egyptian HA sequences, the grebe HA sequence, A/great crested grebe/Qinghai/1/2009, had evidence of recombination with Qinghai clade 2.2.1 sequences from Egypt. The recent grebe sequences came from an isolate collected a year ago at Qinghai Lake. Two years ago similar wild bird Fujian clade 2.3.2 sequences were found at Uvs Lake in Mongolia, bordering Siberia. Therefore, the migration of Fujian sequences to Egypt was expected.However, the recent sequences included obvious recombinants. The Qinghai Lake sequence was Fujian with extensive areas at the 5' end of the gene which matched clade 2.2.1 sequences in Egypt. Similarly, the sequences in Egypt were clade 2.2.1 which acquired Fujian polymorphisms, including the Fujian HA cleavage site in one of the 2008 Egyptian isolates, A/chicken/Egypt/36-4/2008.
The recombination evidence extended beyond the two isolates with extensive recombination. Shorter regions involving two or three consecutive polymorphisms were common in the Egyptian sequences from Harbin (see here). Moreover shared single nucleotide polymorphism were frequent found in Qinghai and Fujian sequences (see examples here), including S125L (see list here).
These data provide compelling evidence for frequent recombination between diverse H5N1 sequences, which represents the dominant driving force behind influenza evolution, and greatly reduces the role of random mutations in genetic drift.
This paradigm shift will have a major impact on vaccine selection and the understanding of evolution.
Egypt has plan to battle Bird flu
The 11 Mar. 2010 at 15:13Last newsComments (0)Add a comment
CAIRO: The Egyptian health ministry said this week that the country is moving ahead with efforts to stall the spread of the deadly avian influenza, or the H5N1 virus, after a surge in reported cases were reported in recent weeks. The ministry hopes that their efforts can curtail the virus from causing a widespread epidemic in the country, or mutating with the swine flu virus to cause what health have feared would be a super virus.The sale of poultry between any of Egypt’s 29 governorates is to be banned, and a major Health Ministry-led awareness campaign will alert the public to the dangers of raising birds at home, Sabir Galal, deputy chief of the Veterinary Medicine Section at the Health Ministry, told local newspapers.
“Bird flu has become endemic in this country … the fear now is that the virus can assume more dangerous forms in the days to come,” he said.
The ministry also said it would stop inoculating birds after vaccines had proved incapable of stopping the virus from spreading.
With 105 infections to date and 30 deaths, Egypt is the world’s third most affected country by avian influenza, according to the World Health Organization. The reason for Egypt’s large number of cases is due to its proximity to three continents and is a regular stopover for migratory birds from Asia, Africa and Europe.
Death toll from A/H1N1 flu reaches 106 in Egypt
The 26 Dec. 2009 at 10:18Last newsComments (0)Add a comment
CAIRO, Dec. 25 (Xinhua) -- Egypt on Friday reported three more death cases of influenza A/H1N1, bringing the nationwide death toll to 106, said the Health Ministry in a statement.A 35-year-old woman in Cairo and another 21-year-old woman in Alexandria died of A/H1N1 virus, said the statement, adding that both suffered from pneumonia and dyspnea.
The third case was a 35-year-old man in Assuit, 330 km south of Cairo, said the statement, adding that he suffered from severe dyspnea.
Earlier on Friday, four million doses of A/H1N1 vaccine were received at Cairo International Airport ahead of a vaccination campaign for school students starting next week, reported Egypt's MENA news agency.
Up till now, Egypt has reported more than 8,500 cases of the novel flu, according to the Health Ministry.
Egypt confirmed its first influenza A/H1N1 death case on July 19. A 28-year-old Egyptian woman, who was back from Saudi Arabia after making Umrah (pilgrimage to Mecca at any time of the year), died of the flu virus.
The most populous Arab country reported its first A/H1N1 flu case on June 2, a 12-year-old Egyptian-American girl coming from the United States via the Netherlands.
Egypt Swine flu deaths rise to 86
The 21 Dec. 2009 at 09:37Last newsComments (0)Add a comment CAIRO: The Egyptian health ministry reported on Sunday a further two new deaths as a result of the H1N1 virus, or Swine flu, bringing the official total of dead in the country from the virus to 86. The ministry said that the deaths were a woman and a young girl from the Gharbiyah and Daqahliyah governorates, respectively.The ministry statement said that the 85th death was a 35-year-old woman from Gharbiyah. She had been taken to the ICU in a local hospital after she was suffering from severe respiratory symptoms. The woman was pregnant.
The statement also noted that the other death was a one-year-old child from Daqahliyah. She was suffering from severe respiratory symptoms as well and was in poor condition when she arrived at a local hospital. She was then transferred to the intensive care unit and placed on a respirator, before succumbing to the illness.
The ministry also announced the deaths of four other cases on Saturday as a result of the H1N1 virus. Abdel Rahman Shahine, the ministry spokesman, said that the 81st death was a 53-years-old woman from Cairo, who died after suffering severe respiratory problems, including pneumonia and was taken to ICU and placed on a respirator, and that her health condition history indicates that she was suffering from Rheumatism , Diabetes, and high blood pressure.
Shaheen said that the 82nd case was a 29-year-old man from the capital, who was suffering from H1N1 and had chronic asthma, diabetes and was obese, while the 83rd case was a 34-year-old man from Alexandria and the 84th was a 54-year-old man from Cairo. His medical record showed that he suffered a stroke.
The official spokesman told Al Dostoor newspaper that Switzerland has apologized for the sale of their surplus of vaccine against swine flu to Egypt, in its response to the request of Minister Hatem Al Gabali for the purchase of their surplus vaccines after the vaccination of all its citizens, adding that negotiations are continuing with the French Government to purchase its surplus of vaccines, in an attempt to buy as much as possible to vaccinate the largest number of Egyptians in order to prevent the spread of the disease internally, noting that the ministry seeks to buy 150,000 doses from France.
To date, Egypt has reported over 4,000 cases of the Swine flu, making it one of the worst affected nations in the Middle East and North Africa.
Six swine flu deaths bring Egypt tally to 77
The 19 Dec. 2009 at 14:39Last newsComments (0)Add a commentCAIRO: Six swine flu related deaths were reported on Thursday, raising Egypt's death toll to 77, according to health ministry spokesperson Abdel Rahman Shahin.
Three cases were announced early Thursday, including two pregnant women, a 23- and a 25-year-old. The third case was of a 12-year-old student.
Later that day three more cases were announced; a 24-year-old man from Cairo who had pneumonia, a 62-year-old man from Giza whose medical history includes coronary artery problems and a seven-month-old boy with a birth defect.
Minister of Health Hatem El-Gabaly is predicting that the number will reach 100 by the end of December and will even continue to rise well into January and February.
Classes and several schools continue to shut down due to an increasing number of swine flu cases among students.
Egypt has reported a total of 1,763 swine flu cases in schools since the beginning of the academic year last October. Of these, 1,440 cases have recovered and 327 are undergoing treatment.
The Ministry of Health reported 937 swine flu cases last week, according to the latest weekly swine flu report.
