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89 swine flu deaths in India this week
The 30 Aug. 2010 at 21:13Last news Comments (0)Add a comment

New Delhi, Aug 30, PTI:

Swine flu continued its grip on India with 89 deaths reported from across the country in the week ending August 29.

Maharashtra reported the maximum number of 50 deaths, followed by 14 from Orissa and six each from Gujarat and Delhi. ive deaths were reported from Madhya Pradesh while four were reported from Andhra Pradesh.

A total of 1,247 cases reported during the week. All are indigenous cases. Till date, samples from 1,67,846 people have been tested for swine flu in government laboratories and a few private laboratories across the country and 39,977 (23.8 per cent) of them have been found positive. The World Health Organisation has officially declared that the swine flu pandemic was over.
by issa - tags : mutation, viral evolution, h1n1, virus, swine flu, 3rd wave, death, d225g, tamiflu resistance, india
H1N1 mutation D225G/N In Recent Australia and New Zealand Cases
The 24 Aug. 2010 at 11:34Last news Comments (0)Add a comment

Recombinomics Commentary 01:11

August 24, 2010

The WHO region center in Australia has released (at GISAID) recent pandemic H1N1 sequences from Australia and New Zealand. Two of the five most recent sequences had D225G or D225N. D225G was in a Victoria (Dandenong), isolate, A/Victoria/502/2010, collected on June 20, 2010 from a 1 month old male infant. The sequence was related to two earlier sequences from Brisbane (collected in April and May).

Further evolution was seen in the four sequences from Christchurch collected between July 5 and 12 from at least two locations (Rakai and Timaru). The most evolved sequence, A/Christchurch/16/2010 (from a 20M), had D225N as well as five additional non-synonymous changes, signaling rapid evolution. All four Christchurch sequences were closely related to each other and had evolved from the Australian sequences. This rapid evolution signals adaptation away from host defenses developed against last season’s vaccine or infections.

The presence of D225G and D225N in the recent isolates raises concerns that these polymorphisms are circulating at higher frequencies than last year. D225G has been strongly linked to severe or fatal cases and an increase frequency in the southern hemisphere can herald similar changes in the northern hemisphere in the upcoming season. The current pandemic target is unchanged from last season, raising concerns that the efficacy of the vaccine will be reduced.

Increases in D225G and D225N were seen at the end of last season and the presence of D225G/N in 2 of the 5 most recent sequences from the southern hemisphere is cause for concern.

by issa - tags : mutation, viral evolution, h1n1, virus, swine flu, 3rd wave, d225g, tamiflu resistance
Bahrein reports two H1N1 Cases
The 24 Aug. 2010 at 01:51Last news Comments (0)Add a comment

Manama Aug 23 (BNA) Bahrain today announced two new cases of swine flu, also known as H1N1. "Lab tests have confirmed the contamination of two Asian men in their thirties", Salmaniya Medical Complex Chief Physician Dr Mohammed Amin Al Awadhi revealed.

The two H1N1 infected patients are being kept in isolation in the intensive care unit, being in critical. They are being monitored and treated with anti-flu medication as they are suffering from breathing problems and other H1N1 complications.

No other H1N11 infections were reported so far at the private companies where they work. Efforts are being coordinated with the Public Health Directorate to ensure the necessary preventive measures and avert a potential H1N1 outbreak.

"Despite the discovery of the new cases, the situation in Bahrain remains assuring" Dr Al Awadhi said, urging caution to avoid potential infection.

Seeking to allay fears, he said such cases are individual and coincide with seasonal flu.

Health Minister Dr Faisal Al Hamer praised SMC doctors for detecting the new H1N1 cases quickly and undertaking the necessary preventive and precautionary measures, directing them to remain on the alert.

GMT 2010/08/23

by issa - tags : mutation, viral evolution, h1n1, swine flu, 3rd wave, tamiflu resistance, d225g, bahrein
4,069 People Began TamiFlu Treatment on Monday in Pune India
The 16 Aug. 2010 at 00:40Last news Comments (0)Add a comment

If someone had told the citizens that the virus would be post-pandemic on Thursday, they may have asked for a treatment deferral . . . unless they trusted their own eyes. No press release can revise the rise of a IDEARRV disease like the ΣPF11 influenza reservoir.

The facts speak for themselves.

On Monday, 2010-08-09, more than 4,000 citizens were placed on TamiFlu treatment in the city of Pune, India. 83 deaths were recorded from pre-post-pandemic influenza for the prior 7 days in that city.

For the country of India, the weekly average confirmed Influenza death count over the past 14 months is slightly above 30 deaths per week. The fatality count from the past week of 83 is 2.7 times the average rate, a substantial acceleration. The Case Fatality Rate varies from 8.8% to 12.1% in the city/district based on the source of data and date bounding. Roughly 1 in 10 people with a confirmed influenza test die in India.

More than 75% of the deaths are in the 20-49 year old age bracket. Years of Life Lost calculations defy all "normal" influenza trends. Traditional influenza has a CFR of less than half a percent and more than 98% of that half percent are over 65 or under 2 years old. These numbers from India in 2010 are not suggestive of a post-pandemic status.

Perhaps we should all just re-base now that we have read the press releases and settle ourselves into this post-pandemic era.

Step 1. We could call 83 deaths per week the new "normal" and post that idea as the rate for "seasonal" influenza. Our forms and percentages will then be quite less concerning to the public. Then we could take a note from the public health textbooks and "estimate using the most advanced models" a normal CFR and game the model variables until we evaluate to the current 8.8% CFR of India.

Step 2. Combine the power of the press with the power of the "expert" credential, even perhaps a committee of experts? In a few pen strokes and an hour here and there behind a microphone, the public would be assuaged and all could return to "business as usual".

Or we could hear the public whose health is suffering, read the data and then tell the truth.

•4,000 on TamiFlu treatment in one day in one city

•83 confirmed deaths in one week in one city

•Post-Pandemic

One of these things is not like the other?

Though we'd like to see the sequences from these fatal cases that are currently accelerating throughout India, a review of the data on file will allow insight into the building / budding process of a pandemic virus into and out of a monsoon climate. An array of FlightPaths may be detected that led to Hydra strains downstream in time. We are under no uncertainty that the viral reservoir will follow a similar route this year.

India, last year, was a testing field for PF11. In a nutshell, the sub-continent had a depth of uptake from Asia and North America that transformed and promoted to Europe and then returned to the United States. That pathway is a generalisation / characterisation and is not comprehensive. Suspicions do lead to a repeat of last year.

Has, perhaps, the 225G on the HA and the 275Y on the NA become more substantial in India after travelling through the world? Is HA 225N playing a role in the more rapid expirations, while cross-linked 225G causes the lingering 3-5 day, ICU-bound feats of ultimate exhaustion? Is a deep, immune escape Hydra carrying HA 165N and 230I at work in the districts showing a 20-29% Case Fatality Rate?

We watch as teams of doctors die, vaccinated doctors, as hospitals with advanced experience and materials lose patients daily to Influenza using immediate TamiFlu blanketing.

Review the sequences that have been made available. See the truth.

. . . . India3725_2010_04_03 (

. . . . . . . . 117T,

. . . . . . . . syn167S,

. . . . . . . . 186P,

. . . . . . . . syn474C,

. . . . . . . . syn526S [Malmoe2_2010_05_07 with 89G])

. . . . IndiaPune10278_2009_09 (

. . . . . . . . syn48R [Norway1359_2009_05_16,

. . . . . . . . . . . . . . UkrZakarpatska830_2009_11_12_f, et al],

. . . . . . . . syn131S [Russia, Afghan, Kenya,

. . . . . . . . . . . . . . NY6943_2009_12_07_xL,

. . . . . . . . . . . . . . Wisconsin, California,

. . . . . . . . . . . . . . Nicaragua, Greece],

. . . . . . . . 206T,

. . . . . . . . 225G,

. . . . . . . . syn413K [H9N2],

. . . . . . . . 454N [H7N3, H7N7, H9N2]

. . . . . . . . . . . . . . [IndiaPune9355_2009_08 with 225G,

. . . . . . . . . . . . . . IndiaBlore236_2009_06_xL with 226R,

. . . . . . . . . . . . . . SouthCarolina18_2009_09_16_VxX,

. . . . . . . . . . . . . . FL_Pen210_2009_11_10],

. . . . . . . . 550T [Unique to India])

. . . . IndiaPune10604_2009_09 (

. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,

. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,

. . . . . . . .. . . . . SingON2416_2009_12_15],

. . . . . . . . syn50V [TexasJMS391_2009_12_23,

. . . . . . . . . . . . . . TexasJMS413_2009_02_03,

. . . . . . . . . . . . . . SouthCarolina02E3_2010_03_05],

. . . . . . . . syn178V (GTt) [NewHampshire02E3_2010_02_19 (GTa)],

. . . . . . . . 206S,

. . . . . . . . 296H,

. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,

. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,

. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,

. . . . . . . . . . . . . . Eng662_2009_08],

. . . . . . . . syn485G [Nebraska 01_2010_01_28,

. . . . . . . . . . . . . . Orenburg2974_2009_11_16_xL,

. . . . . . . . . . . . . . NagasakiHA10_22_2010_03_01])

. . . . IndiaDelhi3704_2009_09 (

. . . . . . . . syn44L,

. . . . . . . . syn106E,

. . . . . . . . syn125S,

. . . . . . . . syn159N,

. . . . . . . . 206T,

. . . . . . . . syn297N,

. . . . . . . . syn413K)

. . . . IndiaNsk10348_2009_09 (

. . . . . . . . #12E,

. . . . . . . . syn33V,

. . . . . . . . 206S,

. . . . . . . . 225G,

. . . . . . . . 296H,

. . . . . . . . syn406R,

. . . . . . . . syn439D)

. . . . IndiaJalna9436_2009_08_30 (

. . . . . . . . 8V [Yaroslavl_KMP_2009_08_25,

. . . . . . . . . . NY7216_2009_12_21 with 225G,

. . . . . . . . . . Utah32_2009_10_14],

. . . . . . . . syn147F [H3N8 Avian, H4, H5, H6, H11],

. . . . . . . . . . . . . . [Yaroslavl_KMP_2009_08_25,

. . . . . . . . . . . . . . IndiaPune21115_2009_12,

. . . . . . . . . . . . . . Athens943_2009_06_12,

. . . . . . . . . . . . . . CalifVRDL99_2009_11_05,

. . . . . . . . . . . . . . Texas44301765_2009_08_30],

. . . . . . . . syn210S,

. . . . . . . . 226R)

. . . . IndiaDelhi3610_2009_08 (

. . . . . . . . syn125S,

. . . . . . . . 157E,

. . . . . . . . 206T,

. . . . . . . . syn294P,

. . . . . . . . syn464G)

. . . . IndiaMum9312_2009_08 (

. . . . . . . . 208K,

. . . . . . . . 225G,

. . . . . . . . syn385V)

. . . . IndiaPune6196_2009_08 (

. . . . . . . . #12E,

. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,

. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,

. . . . . . . .. . . . . SingON2416_2009_12_15],

. . . . . . . . syn152I,

. . . . . . . . 206S,

. . . . . . . . 296H,

. . . . . . . . syn300P (CCt) [H5N1, H6N1, H7N3, H7N7],

. . . . . . . . . . . . . . . . . [Virginia24_2009_06_03 (CCt),

. . . . . . . . . . . . . . . . . NY0352_2009_12_27 (CCt),

. . . . . . . . . . . . . . . . . SingON2416_2009_12_15 (CCa),

. . . . . . . . . . . . . . . . . Vietnam2043_2009_12_01_TmX (CCa),

. . . . . . . . . . . . . . . . . HunanFur129_2010_01_13 (CCa),

. . . . . . . . . . . . . . . . . Slovenia5613_2009_12 (CCa),

. . . . . . . . . . . . . . . . . Minnesota40_2009_11_19 (CCa) w syn252V],

. . . . . . . . 342R,

. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,

. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,

. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,

. . . . . . . . . . . . . . Eng662_2009_08],

. . . . . . . . syn355H [H2, H5N1, H6N1],

. . . . . . . . . . . . . . [MoscowOb_ZNF_2009_11_24_xL_f,

. . . . . . . . . . . . . . MoscowOb_STV_2009_11_09_f with 225N,

. . . . . . . . . . . . . . Ivanovo_STV1_2009_11_21 with 225G,

. . . . . . . . . . . . . . WiscD0589_2009_06_03])

. . . . IndiaPune9355_2009_08 (

. . . . . . . . #10T,

. . . . . . . . syn#4Y [GermanyBY74_2009 with 225G & 226R,

. . . . . . . . . . . . . FL_Pensacola40_2009_11_09],

. . . . . . . . 206T,

. . . . . . . . 225G,

. . . . . . . . syn372Q [H2, H3N8, H4, H5, H6, H7N3, H7N7, H9N2, H11]

. . . . . . . . . . . . . . [IndiaBlore236_2009_06_xL with 226R,

. . . . . . . . . . . . . . Ulyanovsk_SHTA_2009_10_31_f_225N,

. . . . . . . . . . . . . . Orenburg2974_2009_11_16_xL,

. . . . . . . . . . . . . . Russia fatal extensive,

. . . . . . . . . . . . . . swIowa35572_2009_12_16,

. . . . . . . . . . . . . . NagasakiHA10_22_2010_03_01],

. . . . . . . . 373K,

. . . . . . . . syn413K [H9N2],

. . . . . . . . 454N [H7N3, H7N7, H9N2]

. . . . . . . . . . . . . [IndiaBlore236_2009_06 with 226R,

. . . . . . . . . . . . . SouthCarolina18_2009_09_16_VxX,

. . . . . . . . . . . . . FL_Pen210_2009_11_10],

. . . . . . . . 550T [Unique to India])

. . . . IndiaDhule9433_2009_08 (

. . . . . . . . #12E,

. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,

. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,

. . . . . . . . . . . . . SingON2416_2009_12_15,

. . . . . . . . . . . . . IndiaPune10604_2009_09, et al],

. . . . . . . . syn152I,

. . . . . . . . 176I,

. . . . . . . . 205W,

. . . . . . . . 206S,

. . . . . . . . 252L (cTG) [Maryland03_2010_01_13 (tTG),

. . . . . . . . . . . . . . . Guangdong2361_2009_11_25 (tTG)],

. . . . . . . . 296H,

. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,

. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,

. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,

. . . . . . . . . . . . . . Eng662_2009_08],

. . . . . . . . syn386I [1918, Unique to PF11])

. . . . IndiaBlore310_2009_07 (

. . . . . . . . syn105R,

. . . . . . . . syn112S,

. . . . . . . . 206T,

. . . . . . . . syn477T)

. . . . IndiaPune807_2009_07 (

. . . . . . . . #12E,

. . . . . . . . syn2N [UkrSumy797_2009_11_13_f ,

. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,

. . . . . . . .. . . . . SingON2416_2009_12_15],

. . . . . . . . 100Q [Unique to PF11],

. . . . . . . . syn104L [CalifVRDL132_2009_12_30,

. . . . . . . . . . . . . . . Texas45122538_2009_09_12,

. . . . . . . . . . . . . . . WiscD0410_2009_09_24,

. . . . . . . . . . . . . . . WiscD1355_2009_09_21],

. . . . . . . . 206S,

. . . . . . . . 296H,

. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,

. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,

. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,

. . . . . . . . . . . . . . Eng662_2009_08],

. . . . . . . . 461E [Unique to PF11])

. . . . IndiaBlore236_2009_06_xL (

. . . . . . . . 226R,

. . . . . . . . syn372Q [H2, H3N8, H4, H5, H6, H7N3, H7N7, H9N2, H11]

. . . . . . . . . . . . . . [IndiaPune9355_2009_08 with 225G,

. . . . . . . . . . . . . . Ulyanovsk_SHTA_2009_10_31_f_225N,

. . . . . . . . . . . . . . Orenburg2974_2009_11_16_xL,

. . . . . . . . . . . . . . Russia fatal extensive,

. . . . . . . . . . . . . . swIowa35572_2009_12_16,

. . . . . . . . . . . . . . NagasakiHA10_22_2010_03_01]),

. . . . . . . . syn413K [H9N2],

. . . . . . . . 454N [H7N3, H7N7, H9N2]

. . . . . . . . . . . . . . [IndiaPune9355_2009_08 with 225G,

. . . . . . . . . . . . . . SouthCarolina18_2009_09_16_VxX,

. . . . . . . . . . . . . . FL_Pen210_2009_11_10],

. . . . . . . . 550T [Unique to India])

. . . . IndiaHyderabad51_2009_05 (

. . . . . . . . 1T,

. . . . . . . . syn74S [swNC13598_2010_03_09_xL_f

. . . . . . . . . . . . . . . . . . with 15 HA + 4 NA revisions],

. . . . . . . . syn144A (GCc) [Rome632_2009_11_23 (GCg)],

. . . . . . . . 206S)

. . . . equineIndiaAhmedabad1_2009_04_26 (H3N8) (

. . . . . . . . syn211K [H3N8],

. . . . . . . . . . . . . . [MXinDRE50617_2009_11_01 with 225G,

. . . . . . . . . . . . . . Niedersachsen330_2009_07_20],

. . . . . . . . et al)

. . . . equineIndiaKatraJammu7_2008_06 (H3N8) (

. . . . . . . . syn211K [H3N8],

. . . . . . . . . . . . . . [MXinDRE50617_2009_11_01 with 225G,

. . . . . . . . . . . . . . Niedersachsen330_2009_07_20],

. . . . . . . . et al)

Please refer to additional studies for further genetic analyses, including the survey on amino acid revisions potentially related to Vaccine Escape. A hyper-morphic, TamiFlu-resistant sequence from the state of Washington in Spring 2010 has recently been profiled with similar zoonotic influences.

This analysis was fueled by baingan bharta and funded with contributions from concerned families, including HOD, BMS, MJV and CSB.
by issa - tags : mutation, viral evolution, h1n1, virus, swine flu, 3rd wave, d225g, death, tamiflu resistance, india
Delhi: swine flu back in city, 5 deaths in single day
The 10 Aug. 2010 at 22:19Last news Comments (0)Add a comment

NEW DELHI: The swine flu threat is back in the capital. On a day when the World Health Organization declared the H1N1 pandemic over, Delhi reported five deaths due to the viral influenza on Tuesday — taking the total number of fatalities caused by the disease this season to 13.

The city has so far recorded 208 confirmed cases this season.

The high death rate from the disease has led to speculation that the H1N1 strain could have mutated to a more virulent form in the second phase. This, however, hasn't been confirmed through laboratory tests.

Debashish Bhattacharya, nodal officer for swine flu in the capital, said three deaths were reported from Ram Manohar Lohia hospital while one patient died at Gangaram hospital and another at Escorts. Four of the victims were aged between 30 and 50 years. Due to the rains, experts said, the virus is likely to spread.

Two of the five patients suffering from swine flu who died on Tuesday were from Haryana and had been referred by private hospitals, said Dr T S Sidhu, MS of RML hospital. ‘‘They were on ventilator. The third patient, a woman who lived in Karol Bagh, had been in the hospital for four days.’’ One of the patients had borderline diabetes, he added.

Since July, the number of swine flu cases has increased sharply and fatalities are high.

‘‘Swine flu cases are expected to increase during the rains. But the increase in number of deaths needs to be investigated. At present, we can only presume that the virus may have mutated or that the patients who succumbed to the flu had underlying diseases which caused death. Delayed diagnosis is also a major reason behind deaths due to swine flu,’’ said Dr Bir Singh, head of community medicine at AIIMS.

Dr Shobha Broor, professor of microbiology at AIIMS, said that the condition is not alarming. ‘‘Till date, we have not observed any change in the strain or increase in virulence of H1N1 strain. Simple influenza also causes death if the patient has underlying problems. Further investigations will be required to find out the reason behind deaths being reported due to viral influenza,’’ she said.

India has recently launched indigenous swine flu vaccines. However, not many have got themselves inoculated possibly due to the fear of side-effects. Meanwhile, WHO director general Margaret Chan said since the 2009 H1N1 virus had ‘‘largely run its course’’, it was no longer considered a pandemic.

Read more: Swine flu back in city, 5 deaths in single day - Delhi - City - The Times of India http://timesofindia.indiatimes.com/city/delhi/Swine-flu-back-in-city-5-deaths-in-single-day/articleshow/6290027.cms#ixzz0wEiuLhro
by issa - tags : mutation, viral evolution, h1n1, virus, swine flu, 3rd wave, d225g, death, tamiflu resistance, india, evolution